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KMID : 1130320080510080886
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Korean Journal of Pediatrics
2008 Volume.51 No. 8 p.886 ~ p.891
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A Case of mixed connective tissue disease presenting initially with Raynaud’s phenomenon
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Kim Soo-Young
Kim Young-Ok
Woo Young-Jong
Choi Young-Seok
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Abstract
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Mixed connective tissue disease (MCTD) is characterized by diverse symptoms including rheumatoid arthritis, scleroderma, systemic lupus erythematosus, and dermatomyositis, associated with high titers of antibodies to extractable nuclear antigen (ENA), especially anti-ribonucleoprotein (anti-RNP) antibody. Since the first report of 25 cases with MCTD in adults, there have been only a few cases of MCTD reported in children. Here, we report a rare childhood case of MCTD in a 7-year-old girl presenting initially with Raynaud’s phenomenon, swollen hands, and ulceration of the right index finger tip followed by alopecia and arthritis during follow-up
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KEYWORD
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Mixed connective tissue disease, Raynaud’s phenomenon, Antibody to ribonucleoprotein
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